Endocrine Abstracts

Introduction: Women with gestational diabetes (GD) have an increased risk of developing future type 2 diabetes mellitus (T2DM). A reclassification oral glucose tolerance test (OGTT) is currently recomended in the postpartum period. However, most studies report a compliance rate below 50% and as low as 23%.Objectives: We aimed to study predictors of missing postpartum OGTT in women with GD.Materials and Methods: Retrospecti...

Introduction: Recent advance of genetic testing has contributed to the diagnosis of hereditary pheochromocytoma and paraganglioma (PPGL). Germline mutations in MYC associated factor X(MAX) are responsible for 1.1% of these PPGL; the median age at onset is 33 years and no reliable penetrance estimation is available for MAX-carriers. The authors present the case of a synchronous bilateral pheochromocytoma that prompted the discovery of a proband of MAX mutation and three other r...

Background: Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a autosomal recessive disorder with only up to 500 reported cases. It is characterized by generalized absence of fat since birth and severe metabolic derangements such as insulin resistance, hyperglycemia and dyslipidemia. Diabetes mellitus generally develops during the second or third decade of life. This is a rare clinical condition, with worldwide prevalence of 1 in 10 million people and incidence of 1:500.000...

Introduction: Vitamin B1 (VB1) deficiency can occur in patients with obesity and after bariatric surgery (BS). Nevertheless, pre-operative measurements of VB1 are still controversial. The relationship between serum VB1 and weight loss after BS has not been reported previously.Objectives: To study the association between pre-operative VB1 levels and weight loss after BS.Methods: Retrospective study of patients submitted to bariatric...

Somatotropin is essential not only for linear growth but also for important metabolic functions. Its deficiency is usually the first and most common endocrinopathy induced by cancer disease and its treatments, mainly cranial irradiation. Although somatotropin replacement therapy is safe and effective in promoting a better linear growth, studies of final height in childhood cancer survivors treated with somatotropin are limited. This study was performed to examine growth outcom...

IntroductionSimultaneous pancreas-kidney transplantation (PKT) has a beneficial effect on the evolution of chronic complications in type 1 diabetic (T1D) patients with terminal chronic kidney disease (CKD). However, the CKD-mineral and bone disorder (CKD-MBD) remains a frequent complication. There are a few studies addressing the long-term evolution of bone mineral density (BMD) in these patients.AimTo charac...

Introduction: Simultaneous pancreas-kidney transplantation remains the best treatment option in type 1 diabetic patients with chronic kidney failure, providing a euglycemic state associated with an improvement on diabetic chronic complications. However, there are only a few studies addressing the potential ischemic deterioration of peripheral arterial disease, due to blood diverting from the iliac artery to the kidney graft.Aim: Evaluate diabetic foot le...

Introduction: Hyperglycaemia has been associated with worse maternal and foetal outcomes as well as higher risk for future type 2 diabetes (T2D).Objectives: We study the association between glucose above diagnostic threshold (GADT) at gestational diabetes (GD) diagnosis and risk of perinatal complications and maternal glucose abnormalities at post-partum.Materials and Methods: Retrospective study based on the national register of G...

Introduction: Gestational diabetes (GD) is defined as a glucose intolerance firstly recognized during pregnancy and it is the severity of hyperglycaemia which is relevant to maternal and foetal risks. The American Diabetes Association (ADA) recommends screening before 15 weeks of gestation for women at risk, using standard diagnostic criteria, and defines early abnormal glucose metabolism as fasting glucose 110-125 mg/dl or HbA1c 5.9-6.4%. However, the benefit of treating wome...